Tye Sin Street (Malay: Lebuh Tye Sin; Penang Hokkien: See1-Tiau3 Lor33 ) is a minor street in George Town, Penang. It is the fourth street after the Prangin Canal in a city area known today as the Seven Streets Precinct. It was built in the late 19th century, when the vegetable farms south of Prangin Canal made way for urban development.
Tye Sin Street was named after Foo Tye Sin, the commissioner who was charged to look into the causes of the 1867 Penang Riots, and whose residence, the Foo Tye Sin Mansion, is located along Light Street.
Tye Sin Street is within the working class neighbourhood of the Seven Street Precinct, which was initially considered for inclusion within George Town's World Heritage Site. It runs from Brick Kiln Road to the west to Bridge Street to the east. It also forms an intersection with McNair Street. Near to that intersection is the junction where Peking Street emerges.