Yeoh Guan Seok Road was named after a Chinese community leader who was a member of the Penang Chinese Chamber of Commerce in the early part of the 20th century. He was schooled at the Penang Free School, where he was the 29th School Captain in 1899. He was elected as a Municipal Commissioner of George Town on 6 December, 1910.
Today Jalan Yeoh Guan Seok is residential in nature. At the junction with Cantonment Road are two apartment blocks, Porta Mas Apartment on the north side and Villa Indah Apartment on the south side. Once a quiet street, it has seen an increase in traffic after the re-routing of traffic routes in Pulau Tikus, turning it into a one-way street with traffic flow from Lebuhraya Codrington to Jalan Cantonment.