Mahaphruttharam Road (Thai: ถนนมหาพฤฒาราม ) is a road in Bangkok, Thailand. It connects Rama IV Road in the north with Charoen Krung Road in the south. In between, it branches off to Khao Lam Road, Charong Krung Alley 29 and 31, and Ni Chong Sawat Alley.
Mahaphruttharam Road is named after Wat Maha Phruttharam Worawihan, which is located on that road. Khlong Phadung Krung Kasem is located to the west of the road.