At the southern end, Lebuhraya Sultan Iskandar starts at the interchange with Jalan Damansara and Jalan Duta, at Damansara Heights. From here, it continues north through the Lake Gardens area. The next interchange is with Jalan Parlimen, which connect to the Parliament Building on the left. Exiting Lebuhraya Mahameru and turning right takes you to the National Monument.
Lebuhraya Mahameru continues north with Istana Selangor on the right and Belvedere Condominium on the left, in the exclusive Kenny Hills neighbourhood. The next interchange is with Jalan Kuching. You can see the Putra World Trade Centre on your right. Lebuhraya Mahameru ends where it is intersected by Sungai Batu. From there onwards, it continues as Jalan Tun Razak.